FOIL is dedicated to developing novel optical imaging technologies for studying the brain
We develop blood flow imaging systems based on laser speckle contrast imaging (LSCI) to study the effects of ischemic stroke and to better understand the physics of dynamic light scattering.
We design and build high-resolution microscopes to study the three-dimensional vascular and neuronal structures of the cortex at depths and resolutions pushing the limits of optical imaging.
We developed an advanced form of LSCI called multi-exposure speckle imaging (MESI) that offers more versatile and robust estimates of blood flow across a wider range of speeds.
We are designing and building translational laser speckle contrast imaging systems for clinical applications such as continuous blood flow monitoring during vascular neurosurgery.
We developed an automated vectorization method to extract blood vessel geometry and vascular statistics directly from large volumes of unsegmented multiphoton microscopy imagery.
We simulate photon propagation through large cortical tissue geometries in order to study the effects of scattering and develop new imaging techniques based on dynamic light scattering.
We developed imaging systems for use with oxygen-sensitive phosphorescent dyes in order to map cortical oxygen tension (pO2) and study its impact on the progression of ischemic stroke.
We design and build custom ultrafast lasers to push the limits of traditional multiphoton microscopy and enable advanced multi-wavelength excitation strategies.
We built a three-dimensional single particle tracking system capable of spatial localization far beyond the diffraction limit for use in studying molecular transport dynamics.