Publications

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2017

In vivo multiphoton imaging of a diverse array of fluorophores to investigate deep neurovascular structure

D. R. Miller, A. M. Hassan, J. W. Jarrett, F. A. Medina, E. P. Perillo, K. Hagan, S. M. S. Kazmi, T. A. Clark, C. T. Sullender, T. A. Jones, B. V. Zemelman, and A. K. Dunn, Biomedical Optics Express (2017)

High-resolution bubble printing of quantum dots

B. B. Rajeeva, L. Lin, E. P. Perillo, X. Peng, W. W. Yu, A. K. Dunn, and Y. Zheng, ACS Applied Materials & Interfaces (2017)

Patterning and fluorescence tuning of quantum dots with haptic-interfaced bubble printing

B. B. Rajeeva, M. A. Alabandi, L. Lin, E. P. Perillo, A. K. Dunn, and Y. Zheng, Journal of Materials Chemistry C (2017)

Ultraflexible nanoelectronic probes form reliable, glial scar–free neural integration

L. Luan, X. Wei, Z. Zhao, J. J. Siegel, O. Potnis, C. A. Tuppen, S. Lin, S. M. S. Kazmi, R. A. Fowler, S. Holloway, A. K. Dunn, R. A. Chitwood, and C. Xie, Science Advances (2017)

Intraoperative multi-exposure speckle imaging of cerebral blood flow

L. M. Richards, S. M. S. Kazmi, K. E. Olin, J. S. Waldron, D. J. Fox, and A. K. Dunn, Journal of Cerebral Blood Flow & Metabolism (2017)

2016

Segmentation of 3D trajectories acquired by TSUNAMI microscope: An application to EGFR trafficking

Y. L. Liu, E. P. Perillo, C. Liu, P. Yu, C. K. Chou, M. C. Hung, A. K. Dunn, and H.C. Yeh, Biophysical Journal (2016)

Syndesome therapeutics for enhancing diabetic wound healing

S. Das, G. Singh, M. Majid, M. B. Sherman, S. Mukhopadhyay, C. S. Wright, P. E. Martin, A. K. Dunn, and A. B. Baker, Advanced Healthcare Materials (2016)

Glypican-1 nanoliposomes for potentiating growth factor activity in therapeutic angiogenesis

A. J. Monteforte, B. Lam, S. Das, S. Mukhopadhyay, C. S. Wright, P. E. Martin, A. K. Dunn, and A. B. Baker, Biomaterials (2016)

Molecular-Fluorescence Enhancement via Blue-Shifted Plasmon-Induced Resonance Energy Transfer

M. Wang, B. B. Rajeeva, L. Scarabelli, E. P. Perillo, A. K. Dunn, L. M. Liz-Marzán, and Y. Zheng, Journal of Physical Chemistry C (2016)

Single-Molecule Tracking and Its Application in Biomolecular Binding Detection

C. Liu, Y. L. Liu, E. P. Perillo, A. K. Dunn, and H. C. Yeh, IEEE Journal of Selected Topics in Quantum Electronics (2016)

Syndecan-4 enhances therapeutic angiogenesis after hind limb ischemia in mice with type 2 diabetes

S. Das, A. J. Monteforte, G. Singh, M. Majid, M. B. Sherman, A. K. Dunn, and A. B. Baker, Advanced Healthcare Materials (2016)

Sensitivity of laser speckle contrast imaging to flow perturbations in the cortex

M. A. Davis, L. Gagnon, D. A. Boas, and A. K. Dunn, Biomedical Optics Express (2016)

Deep in vivo two­-photon microscopy with a low cost custom built mode-­locked 1060 nm fiber laser

E. P. Perillo, J. E. McCracken, D. C. Fernée, J. R. Goldak, F. A. Medina, D. R. Miller, H. C. Yeh, and A. K. Dunn, Biomedical Optics Express (2016)

2015

Bubble-Pen Lithography

L. Lin, X. Peng, Z. Mao, W. Li, M. N. Yogeesh, B. B. Rajeeva, E. P. Perillo, A. K. Dunn, D. Akinwande, and Y. Zheng, Nano Letters (2015)

Regioselective localization and tracking of biomolecules on single gold nanoparticles

B. B. Rajeeva, D. S. Hernandez, M. Wang, E. P. Perillo, L. Lin, L. Scarabelli, B. Pingali, L. M. Liz-Marzán, A. K. Dunn, J. B. Shear, and Y. Zheng, Advanced Science (2015)

Improving z­-tracking accuracy in the two-photon single-particle tracking microscope

C. Liu, Y. L. Liu, E. P. Perillo, N. Jiang, A. K. Dunn, and H. C. Yeh, Applied Physics Letters (2015)

Evaluating multi-exposure speckle imaging estimates of absolute autocorrelation times

S. M. S. Kazmi, R. K. Wu, and A. K. Dunn, Optics Letters (2015)

Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination

E. P. Perillo, Y. L. Liu, K. Huynh, C. Liu, C. K. Chou, M. C. Hung, H. C. Yeh, and A. K. Dunn, Nature Communications (2015)

Dynamic light scattering Monte Carlo: a method for simulating time-varying dynamics for ordered motion in heterogeneous media

M. A. Davis and A. K. Dunn, Optics Express (2015)

Flux or speed? Examining speckle contrast imaging of vascular flows

S. M. S. Kazmi, E. Faraji, M. A. Davis, Y. Huang, X. J. Zhang, and A. K. Dunn, Biomedical Optics Express (2015)

Expanding applications, accuracy, and interpretation of laser speckle contrast imaging of cerebral blood flow

S. M. S. Kazmi, L. M. Richards, C. J. Schrandt, M. A. Davis, and A. K. Dunn, Journal of Cerebral Blood Flow & Metabolism (2015)

Chronic monitoring of vascular progression after ischemic stroke using multiexposure speckle imaging and two-photon fluorescence microscopy.

C. J. Schrandt, S. M. S. Kazmi, T. A. Jones, and A. K. Dunn, Journal of Cerebral Blood Flow & Metabolism (2015)

2014

Intraoperative laser speckle contrast imaging with retrospective motion correction for quantitative assessment of cerebral blood flow

L. M. Richards, E. L. Towle, D. J. Fox, and A. K. Dunn, Neurophotonics (2014)

Imaging depth and multiple scattering in laser speckle contrast imaging

M. A. Davis, S. M. S. Kazmi, A. K. Dunn, Journal of Biomedical Optics (2014)

Rapid computation of the amplitude and phase of tightly focused optical fields distorted by scattering particles

J. C. Ranasinghesagara, C. K. Hayakawa, M. A. Davis, A. K. Dunn, E. O. Potma, V. Venugopalan, Journal of the Optical Society of America A (2014)

Optimization of camera exposure durations for multi-exposure speckle imaging of the microcirculation

S. M. S. Kazmi, S. Balial, A. K. Dunn, Biomedical Optics Express (2014)

Quantification of thermal lensing using an artificial eye

E. L. Towle, M. Rickman, A. K. Dunn, A. J. Welch, R. J. Thomas, IEEE Journal on Selected Topics in Quantum Electronics (2014)

Loss of Syndecan-1 Induces a Pro-Inflammatory Phenotype in Endothelial Cells with a Dysregulated Response to Atheroprotective Flow

P. L. Voyvodic, D. Min, R. Liu, E. Williams, V. Chitalia, A. K. Dunn, A. B. Baker, The Journal of Biological Chemistry (2014)

Focusing light within turbid media with weakly discriminating filters

J. W. Tom and A. K. Dunn, Journal of the Optical Society of America B (2014)

Optical Properties of Neural Tissue

A. K. Dunn, Optical Imaging of Neocortical Dynamics (2014)

2013

Low-cost laser speckle contrast imaging of blood flow using a webcam

L. M. Richards, S. M. S. Kazmi, J. L. Davis, K. E. Olin, and A. K. Dunn, Biomedical Optics Express (2013)

Laser speckle contrast imaging of blood flow in rat retinas using an endoscope

A. Ponticorvo, D. Cardenas, A. K. Dunn, D. Ts’o, and T. Q. Duong, Journal of Biomedical Optics (2013)

Three-dimensional mapping of oxygen tension in cortical arterioles before and after occlusion

S. M. S. Kazmi, A. J. Salvaggio, A. D. Estrada, M. A. Hemati, N. K. Shaydyuk, E. Roussakis, T. A. Jones, S. A. Vinogradov, and A. K. Dunn, Biomedical Optics Express (2013)

Chronic imaging of cortical blood flow using Multi-Exposure Speckle Imaging.

S. M. S. Kazmi, A. B. Parthasarthy, N. E. Song, T. A. Jones, and A. K. Dunn, Journal of Cerebral Blood Flow & Metabolism (2013)

Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation.

B. Yin, R. V. Kuranov, A. B. McElroy, S. M. S. Kazmi, A. K. Dunn, T. Q. Duong, and T. E. Milner, Journal of Biomedical Optics (2013)

2012

Comparison of indocyanine green angiography and laser speckle contrast imaging for the assessment of vasculature perfusion

E. L. Towle, L. M. Richards, S. M. S. Kazmi, D. J. Fox, and A. K. Dunn, Neurosurgery (2012)

Visual disruption using the thermal lensing effect in the human eye: pilot study

E. L. Towle, P. V. Garcia, P. A. Smith, R. J. Thomas, A. K. Dunn, A. J. Welch, and B. K. Foutch, Journal of Biomedical Optics (2012)

Narrow band imaging of squamous cell carcinoma tumors using topically delivered anti-EGFR antibody conjugated gold nanorods

P. Puvanakrishnan, P. Diagaradjane, S. M. S. Kazmi, A. K. Dunn, S. Krishnan, and J. W. Tunnell, Lasers in Surgery and Medicine (2012)

Laser speckle contrast imaging of cerebral blood flow

A. K. Dunn, Annals of Biomedical Engineering (2012)

Combined two-photon luminescence microscopy and OCT for macrophage detection in the hypercholesterolemic rabbit aorta using plasmonic gold nanorose

T. Wang, J. J. Mancuso, S. M. S. Kazmi, J. Dwelle, V. Sapozhnikova, B. Willsey, L. L. Ma, J. Qiu, X. Li, A. K. Dunn, K. P. Johnston, M. D. Feldman, and T. E. Milner, Lasers in Surgery and Medicine (2012)

2011

Depth dependence of vascular fluorescence imaging

M. A. Davis, S. M. S. Kazmi, A. Ponticorvo, and A. K. Dunn, Biomedical Optics Express (2011)

In vivo depth-resolved oxygen saturation by dual-wavelength photothermal (DWP) OCT

R. V. Kuranov, S. M. S. Kazmi, A. B. McElroy, J. W. Kiel, A. K. Dunn, T. E. Milner, and T. Q. Duong, Optics Express (2011)

Measurements and modeling of transient blood flow perturbations induced by brief somatosensory stimulation

K. Swanul, A. K. Dunn, T. Q. Duong, and D. Ress, The Open Neuroimaging Journal (2011)

Introduction: feature issue on In Vivo Microcirculation Imaging

A. K. Dunn, R. Leitgeb, R. K. Wang, and H. F. Zhang, Biomedical Optics Express (2011)

Thrombotic distal middle cerebral artery occlusion produced by topical FeCl3 application: a novel model suitable for intravital microscopy and thrombolysis studies

H. Karatas, S. E. Erdener, Y. Gursoy-Ozdemir, G. Gurer, F. Soylemezoglu, A. K. Dunn, and T. Dalkara, Journal of Cerebral Blood Flow & Metabolism (2011)

Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography

R. V. Kuranov, J. Qiu, A. B. McElroy, A. Estrada, A. Salvaggio, J. Kiel, A. K. Dunn, T. Q. Duong, and T. E. Milner, Biomedical Optics Express (2011)

2010

Laser speckle contrast imaging of cerebral blood flow in humans during neurosurgery: a pilot clinical study

A. B. Parthasarathy, E. L. Weber, L. M. Richards, D. J. Fox, and A. K. Dunn, Journal of Biomedical Optics (2010)

How to build a Laser Speckle Contrast Imaging (LSCI) system to monitor blood flow.

A. Ponticorvo and A. K. Dunn, Journal of Visualized Experiments (2010)

Far-field superposition method for three-dimensional computation of light scattering from multiple cells

M. S. Starosta and A. K. Dunn, Journal of Biomedical Optics (2010)

Intra-organ biodistribution of gold nanoparticles using intrinsic two-photon-induced photoluminescence

J. Park, A. Estrada, J. A. Schwartz, P. Diagaradjane, S. Krishnan, A. K. Dunn, and J. W. Tunnell, Lasers in Surgery and Medicine (2010)

Quantitative imaging of ischemic stroke through thinned skull in mice with Multi Exposure Speckle Imaging

A. B. Parthasarathy, S. M. S. Kazmi, and A. K. Dunn, Biomedical Optics Express (2010)

Spreading depolarizations cycle around and enlarge focal ischaemic brain lesions

H. Nakamura, A. J. Strong, C. Dohmen, O. W. Sakowitz, S. Vollmar, M. Sue, L. Kracht, P. Hashemi, R. Bhatia, T. Yoshimine, J. P. Dreier, A. K. Dunn, and R. Graf, Brain (2010)

Improved sensitivity for two-photon frequency-domain lifetime measurement

A. D. Estrada and A. K. Dunn, Optics Express (2010)

Simultaneous imaging of oxygen tension and blood flow in animals using a digital micromirror device

A. Ponticorvo and A. K. Dunn, Optics Express (2010)

Laser speckle contrast imaging in biomedical optics

D. A. Boas and A. K. Dunn, Journal of Biomedical Optics (2010)

2009

Perfusion in hamster skin treated with glycerol

R. T. Zaman, A. B. Parthasarathy, G. Vargas, B. Chen, A. K. Dunn, H. G. Rylander, and A. J. Welch, Lasers in Surgery and Medicine (2009)

Sensitivity of neural-hemodynamic coupling to alterations in cerebral blood flow during hypercapnia

T. J. Huppert, P. B. Jones, A. Devor, A. K. Dunn, I. C. Teng, A. M. Dale, and D. A. Boas, Journal of Biomedical Optics (2009)

Three-dimensional computation of focused beam propagation through multiple biological cells

M. S. Starosta and A. K. Dunn, Optics Express (2009)

2008

Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex

A. Devor, E. Hillman, P. Tian, C. Waeber, I. C. Teng, L. Ruvinskaya, M. H. Shalinsky, H. Zhu, R. H. Haslinger, S. N. Narayanan, I. Ulbert, A. K. Dunn, E. H. Lo, B. R. Rosen, A. M. Dale, D. Kleinfeld, and D. A. Boas, The Journal of Neuroscience (2008)

Efficient processing of laser speckle contrast images

W. J. Tom, A. Ponticorvo, and A. K. Dunn, IEEE Transactions on Medical Imaging (2008)

A time domain fluorescence tomography system for small animal imaging

A. Kumar, S. B. Raymond, A. K. Dunn, B. J. Bacskai, and D. A. Boas, IEEE Transactions on Medical Imaging (2008)

Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia

P. B. Jones, H. K. Shin, D. A. Boas, B. T. Hyman, M. A. Moskowitz, C. Ayata, and A. K. Dunn, Journal of Biomedical Optics (2008)

Microvascular oxygen quantification using two-photon microscopy

A. D. Estrada, A. Ponticorvo, T. N. Ford, and A. K. Dunn, Optics Letters (2008)

Two-photon-induced photoluminescence imaging of tumors using near-infrared excited gold nanoshells

J. Park, A. Estrada, K. Sharp, K. Sang, J. A. Schwartz, D. K. Smith, C. Coleman, J. D. Payne, B. A. Korgel, A. K. Dunn, and J. W. Tunnell, Optics Express (2008)

Robust flow measurement with multi-exposure speckle imaging

A. B. Parthasarathy, W. J. Tom, A. Gopal, X. Zhang, and A. K. Dunn, Optics Express (2008)

2007

Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia

H. K. Shin, A. K. Dunn, P. B. Jones, D. A. Boas, E. H. Lo, M. A. Moskowitz, and C. Ayata, Brain (2007)

Cortical blood flow assessment with frequency-domain laser Doppler microscopy

M. Atlan, B. C. Forget, A. C. Boccara, T. Vitalis, A. Rancillac, A. K. Dunn, and M. Gross, Journal of Biomedical Optics (2007)

Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex

A. J. Strong, P. J. Anderson, H. R. Watts, D. J. Virley, A. Lloyd, E. A. Irving, T. Nagafuji, M. Ninomiya, H. Nakamura, A. K. Dunn, and R. Graf, Brain (2007)

Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation

E. Hillman, A. Devor, M. B. Bouchard, A. K. Dunn, G. W. Krauss, J. Skoch, B. J. Bacskai, A. M. Dale, and D. A. Boas, NeuroImage (2007)

2006

Frequency-domain wide-field laser Doppler in vivo imaging

M. Atlan, M. Gross, B. C. Forget, T. Vitalis, A. Rancillac, and A. K. Dunn, Optics Letters (2006)

Vasoconstrictive neurovascular coupling during focal ischemic depolarizations

H. K. Shin, A. K. Dunn, P. B. Jones, D. A. Boas, M. A. Moskowitz, and C. Ayata, Journal of Cerebral Blood Flow & Metabolism (2006)

Evaluation of laser speckle flowmetry for imaging cortical perfusion in experimental stroke studies: quantitation of perfusion and detection of peri-infarct depolarisations

A. J. Strong, E. L. Bezzina, P. J. Anderson, M. G. Boutelle, S. E. Hopwood, and A. K. Dunn, Journal of Cerebral Blood Flow & Metabolism (2006)

2005

Fluorescence-lifetime-based tomography for turbid media

A. T. N Kumar, J. Skoch, B. J. Bacskai, D. A. Boas, and A. K. Dunn, Optics Letters (2005)

Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex

A. K. Dunn, A. Devor, A. M. Dale, and D. A. Boas, NeuroImage (2005)

Heterodyne detection of multiply scattered monochromatic light with a multipixel detector

M. Gross, P. Goy, B. C. Forget, M. Atlan, F. Ramaz, A. C. Boccara, and A. K. Dunn, Optics Letters (2005)

Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging

S. Yuan, A. Devor, D. A. Boas, and A. K. Dunn, Applied Optics (2005)

Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity

A. Devor, I. Ulbert, A. K. Dunn, S. N. Narayanan, S. R. Jones, M. L. Andermann, D. A. Boas, and A. M. Dale, Proceedings of the National Academy of Sciences of the United States of America (2005)

Development of an optical approach for noninvasive imaging of Alzheimer’s disease pathology

J. Skoch, A. K. Dunn, B. T. Hyman, and B. J. Bacskai, Journal of Biomedical Optics (2005)

2004

Pronounced hypoperfusion during spreading depression in mouse cortex

C. Ayata, H. K. Shin, S. Salomone, Y. Ozdemir-Gursoy, D. A. Boas, A. K Dunn, and M. A. Moskowitz, Journal of Cerebral Blood Flow & Metabolism (2004)

Computational microscopy in embryo imaging

J. L. Hollmann, A. K. Dunn, and C. A. Dimarzio, Optics Letters (2004)

Mouse model of microembolic stroke and reperfusion

D. N. Atochin, J. C. Murciano, Y. Gürsoy-Özdemir, T. Krasik, F. Noda, C. Ayata, A. K. Dunn, M. A. Moskowitz, P. L. Huang, and V. R. Muzykantov, Stroke (2004)

Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media

E. M. C. Hillman, D. A. Boas, A. M. Dale, and A. K. Dunn, Optics Letters (2004)

Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex

C. Ayata, A. K. Dunn, Y. Gursoy-OZdemir, Z. Huang, D. A. Boas, and M. A. Moskowitz, Journal of Cerebral Blood Flow & Metabolism (2004)

2003

Coupling of Total Hemoglobin Concentration, Oxygenation, and Neural Activity in Rat Somatosensory Cortex

A. Devor, A. K. Dunn, M. L. Andermann, I. Ulbert, D. A. Boas, and A. M. Dale, Neuron (2003)

Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation

A. K. Dunn, A. Devor, H. Bolay, M. L. Andermann, M. A. Moskowitz, A. M. Dale, and D. A. Boas, Optics Letters (2003)

2002

Three dimensional Monte Carlo code for photon migration through complex heterogeneous media including the adult human head

D. A. Boas, J. P. Culver, J. J. Stott, and A. K. Dunn, Optics Express (2002)

Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model

H. Bolay, U. Reuter, A. K. Dunn, Z. Huang, D. A. Boas, M. A. Moskowitz, Nature Medicine (2002)

2001

Perturbation Monte Carlo methods to solve inverse photon migration problems in heterogeneous tissues

C. K. Hayakawa, J. Spanier, F. Bevilacqua, A. K. Dunn, J. S. You, B. J. Tromberg, and V. Venugopalan, Optics Letters (2001)

Dynamic imaging of cerebral blood flow using laser speckle

A. K. Dunn, H. Bolay, M. A. Moskowitz, and D. A. Boas, Journal of Cerebral Blood Flow & Metabolism (2001)

2000

Transport-based image reconstruction in turbid media with small source–detector separations

A. K. Dunn and D. A. Boas, Optics Letters (2000)

Gene inactivation by multiphoton-targeted photochemistry.

M. W. Berns, Z. Wang, A. K. Dunn, V. Wallace, and V. Venugopalan, Proceedings of the National Academy of Sciences of the United States of America (2000)

A pulsed finite-difference time-domain (FDTD) method for calculating light scattering from biological cells over broad wavelength ranges

R. Drezek, A. K. Dunn, and R. Richards-Kortum, Optics Express (2000)

Influence of optical properties on two-photon fluorescence imaging in turbid samples

A. K. Dunn, V. P. Wallace, M. Coleno, M. W. Berns, and B. J. Tromberg, Applied Optics (2000)

1999

Light scattering from cells: finite-difference time-domain simulations and goniometric measurements

R. Drezek, A. K. Dunn, and R. Richards-Kortum, Applied Optics (1999)

1998

Near real time confocal microscopy of cultured amelanotic cells: sources of signal, contrast agents and limits of contrast

C. Smithpeter, A. K. Dunn, R. Drezek, T. Collier, and R. Richards-Kortum, Journal of Biomedical Optics (1998)

Penetration depth limits of in vivo confocal reflectance imaging

C. Smithpeter, A. K. Dunn, A. J. Welch, and R. Richards-Kortum, Applied Optics (1998)

Optical model for light distribution during transscleral cyclophotocoagulation

B. Nemati, A. K. Dunn, A. J. Welch, and H. G. Rylander, Applied Optics (1998)

1997

Finite-difference time-domain simulation of light scattering from single cells

A. K. Dunn, C. Smithpeter, A. J. Welch, and R. Richards-Kortum, Journal of Biomedical Optics (1997)

1996

Three-dimensional computation of light scattering from cells

A. K. Dunn and R. Richards-Kortum, IEEE Journal of Special Topics in Quantum Electronics (1996)

Sources of contrast in confocal reflectance imaging

A. K. Dunn, C. Smithpeter, R. Richards-Kortum, and A. J. Welch, Applied Optics (1996)

Efficient computation of time-resolved transfer functions for imaging in turbid media

A. K. Dunn and C. DiMarzio, Journal of the Optical Society of America A (1996)