Clinical Speckle Imaging

Intraoperative LSCI (Richards, 2014)

Monitoring cerebral blood flow (CBF) during neurosurgery can provide important physiological information during a variety of highly-invasive procedures. These measurements could be useful for assessing whether blood flow has returned to presurgical baseline levels or for determining postsurgical tissue viability. Laser speckle contrast imaging (LSCI) has been used extensively for quantitative CBF imaging during preclinical research with animal models.

We are working to develop translational LSCI systems for real-time clinical applications during neurovascular procedures such aneurysm clippings or tumor resections. Our current designs adapt onto commercial neurosurgical microscopes (Fig. 1) and allow for continuous CBF imaging without disrupting normal use.

Schematic of hardware adapted to Zeiss OPMI Pentero neurosurgical microscope for intraoperative LSCI ([Richards, 2017](/publication/richards-2017/)).
Schematic of hardware adapted to Zeiss OPMI Pentero neurosurgical microscope for intraoperative LSCI (Richards, 2017).
Aneurysm Clipping: Intraoperative LSCI captures the pulsatile filling of an aneurysm during the cardiac cycle and the elimination of blood flow following clip placement during surgery (Miller, 2022).
Clinical LSCI MESI

Publications

David Miller, Ramsey Ashour, Colin Sullender, Andrew Dunn. Continuous blood flow visualization with laser speckle contrast imaging during neurovascular surgery. Neurophotonics, 2022.
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Lisa Richards, S. M. Shams Kazmi, Katherine Olin, James Waldron, Andrew Dunn. Intraoperative multi-exposure speckle imaging of cerebral blood flow. Journal of Cerebral Blood Flow & Metabolism, 2017.
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Lisa Richards, Erica Towle, Douglas Fox, Andrew Dunn. Intraoperative laser speckle contrast imaging with retrospective motion correction for quantitative assessment of cerebral blood flow. Neurophotonics, 2014.
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S. M. Shams Kazmi, Lisa Richards, Andrew Dunn. Cerebral Blood Flow Imaging with Laser Speckle Contrast Imaging. Neurovascular Coupling Methods, 2014.
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Lisa Richards, Erica Towle, Douglas Fox, Andrew Dunn. Laser Speckle Imaging of Cerebral Blood Flow. Optical Methods and Instrumentation in Brain Imaging and Therapy, 2012.
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Ashwin Parthasarathy, Erica Weber, Lisa Richards, Andrew Dunn. Laser speckle contrast imaging of cerebral blood flow in humans during neurosurgery: a pilot clinical study. Journal of Biomedical Optics, 2010.
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