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Computational microscopy in embryo imaging
The growth of computing power has greatly improved our ability to extract quantitative information about complicated three-dimensional …
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Pronounced hypoperfusion during spreading depression in mouse cortex
We studied unique cerebral blood flow (CBF) responses to cortical spreading depression in mice using a novel two-dimensional CBF …
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Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media
Laminar optical tomography (LOT) is a new technique that combines the advantages of diffuse optical tomography image reconstruction and …
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Mouse model of microembolic stroke and reperfusion

Background and Purpose: To test the role of fibrinolysis in stroke, we used a mouse model in which preformed 2.5- to 3-µm-diameter …

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Laser Speckle Flowmetry for the Study of Cerebrovascular Physiology in Normal and Ischemic Mouse Cortex
Laser speckle flowmetry (LSF) is useful to assess noninvasively two-dimensional cerebral blood flow (CBF) with high temporal and …
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Coupling of Total Hemoglobin Concentration, Oxygenation, and Neural Activity in Rat Somatosensory Cortex

Recent advances in brain imaging techniques, including functional magnetic resonance imaging (fMRI), offer great promise for …

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Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation
A simple instrument is demonstrated for high-resolution simultaneous imaging of total hemoglobin concentration and oxygenation and …
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Three dimensional Monte Carlo code for photon migration through complex heterogeneous media including the adult human head
We describe a novel Monte Carlo code for photon migration through 3D media with spatially varying optical properties. The code is …
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Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model
Although the trigeminal nerve innervates the meninges and participates in the genesis of migraine headaches, triggering mechanisms …
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Perturbation Monte Carlo methods to solve inverse photon migration problems in heterogeneous tissues
We introduce a novel and efficient method to provide solutions to inverse photon migration problems in heterogeneous turbid media. The …
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