12/15-Lipooxygenase inhibition reduces microvessel constriction and microthrombi after subarachnoid hemorrhage in mice

Ari Dienel, Sung Ha Hong, Hussein A. Zeineddine, Sithara Thomas, Dania A. Jose, Kiara Torres, Jose Guzman, Andrew Dunn, Gadiparthi N. Rao, Spiros L. Blackburn, Devin W. McBride
August 2025
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Abstract

The study investigates the role of 12/15-Lipooxygenase (12/15-LOX) in microvessel constriction and microthrombi formation following subarachnoid hemorrhage (SAH) in mice. The findings suggest that inhibiting 12/15-LOX may prevent delayed cerebral ischemia after SAH.

Type
Journal article
Publication
Translational Stroke Research
Stroke Collaboration

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