Laser speckle contrast imaging is a widefield, real-time optical imaging method with high spatial and temporal resolution that can be used to measure blood flow dynamics.
We utilize two- and three-photon microscopy to image the microvascular architecture of blood vessels supplying the cortical layers of the mouse brain.
TSUNAMI is a 3D particle tracking system capable of quantifying molecular transport dynamics with spatial localization precision up to 35nm.
We combine multiple imaging techniques to simultaneously image multiple hemodynamic parameters in the ischemic brain.
We use computer simulations to numerically model photon propagation in tissue geometries in order to better understand the effects of scattering and its effect on imaging depth.
We utilize optical coherence tomography to study neurovascular blood flow in order to better understand dynamic light scattering.