Studying neurovascular blood flow function in cerebrovascular activities requires accurate visualization and characterization of blood flow volume as well as the dynamics of blood cells in microcirculation. Absolute measurement of blood cells and blood volume requires the acquisition of high-resolution volumetric structural and functional information.
We utilize optical coherence tomography (OCT) to perform micro-resolution 3D imaging of the mouse brain. Our spectral domain OCT (SD-OCT) system uses coherence gating to measure scattered light from a small volume with high structural resolution. The system can rapidly assess large regions of capillaries for spatio-temporal tracking of red blood cells.