2P

We design and build high-resolution microscopes to study the three-dimensional vascular and neuronal structures of the cortex at depths and resolutions pushing the limits of optical imaging.

We developed imaging systems for use with oxygen-sensitive phosphorescent dyes in order to map cortical oxygen tension (pO2) and study its impact on the progression of ischemic stroke.

We design and build custom ultrafast lasers to push the limits of traditional multiphoton microscopy and enable advanced multi-wavelength excitation strategies.

We built a three-dimensional single particle tracking system capable of spatial localization far beyond the diffraction limit for use in studying molecular transport dynamics.

A potential method for tracking neurovascular disease progression over time in preclinical models is multiphoton fluorescence …

Here we introduce a fiber amplifier and a diamond Raman laser that output high powers (6.5 W, 1.3 W) at valuable wavelengths (1060 nm, …

We demonstrate a simple, low-cost two-photon microscope design with both galvo-galvo and resonant-galvo scanning capabilities. We …

Recent advances in two-photon fluorescence microscopy (2PM) have allowed large scale imaging and analysis of blood vessel networks in …

Recent advancements in multiphoton imaging and vascular reconstruction algorithms have increased the amount of data on cerebrovascular …

Brain injury causes astrocytes to assume a reactive state that is essential for early tissue protection, but how reactive astrocytes …