2P

Intra-organ biodistribution of gold nanoparticles using intrinsic two-photon-induced photoluminescence

Background and Objectives: Gold nanoparticles (GNPs) such as gold nanoshells (GNSs) and gold nanorods (GNRs) have been explored in a …

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Improved sensitivity for two-photon frequency-domain lifetime measurement
We demonstrate a method to improve the measurement sensitivity of two-photon frequency-domain lifetime measurements in poor signal to …
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Stimulus-Induced Changes in Blood Flow and 2-Deoxyglucose Uptake Dissociate in Ipsilateral Somatosensory Cortex
The present study addresses the relationship between blood flow and glucose consumption in rat primary somatosensory cortex (SI) in …
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Microvascular oxygen quantification using two-photon microscopy
An instrument is demonstrated that is capable of three-dimensional (3D) vasculature imaging and $p_{O_2}$ quantification with high …
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Two-photon-induced photoluminescence imaging of tumors using near-infrared excited gold nanoshells
Gold nanoshells (dielectric silica core/gold shell) are a novel class of hybrid metal nanoparticles whose unique optical properties …
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Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation

The cortical hemodynamic response to somatosensory stimulus is investigated at the level of individual vascular compartments using both …

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Influence of optical properties on two-photon fluorescence imaging in turbid samples
A numerical model was developed to simulate the effects of tissue optical properties, objective numerical aperture (N.A.), and …
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