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Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia
Real-time investigation of cerebral blood flow (CBF), and oxy- and deoxyhemoglobin concentration (HbO, HbR) dynamics has been difficult …
Phill Jones
,
Hwa Kyoung Shin
,
David Boas
,
Bradley Hyman
,
Michael Moskowitz
,
Cenk Ayata
,
Andrew Dunn
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Efficient Processing of Laser Speckle Contrast Images
Though laser speckle contrast imaging enables the measurement of scattering particle dynamics with high temporal resolution, the …
W. James Tom
,
Adrien Ponticorvo
,
Andrew Dunn
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Robust flow measurement with multi-exposure speckle imaging
Laser Speckle Contrast Imaging (LSCI) is a minimally invasive full field optical technique used to generate blood flow maps with high …
Ashwin Parthasarathy
,
W. James Tom
,
Ashwini Gopal
,
Xiaojing Zhang
,
Andrew Dunn
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Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia
Normobaric hyperoxia is under investigation as a treatment for acute ischaemic stroke. In experimental models, normobaric hyperoxia …
Hwa Kyoung Shin
,
Andrew Dunn
,
Phillip Jones
,
David Boas
,
Eng Lo
,
Michael Moskowitz
,
Cenk Ayata
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Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex
In the light of accumulating evidence for the occurrence of spontaneous cortical spreading depression and peri-infarct depolarizations …
Anthony Strong
,
Peter Anderson
,
Helena Watts
,
David Virley
,
Andrew Lloyd
,
Elaine Irving
,
Toshiaki Nagafuji
,
Mitsuyoshi Ninomiya
,
Hajime Nakamura
,
Andrew Dunn
,
Rudolf Graf
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Vasoconstrictive neurovascular coupling during focal ischemic depolarizations
Ischemic depolarizing events, such as repetitive spontaneous periinfarct spreading depolarizations (PIDs), expand the infarct size …
Hwa Kyoung Shin
,
Andrew Dunn
,
Phillip Jones
,
David Boas
,
Michael Moskowitz
,
Cenk Ayata
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Evaluation of laser speckle flowmetry for imaging cortical perfusion in experimental stroke studies: quantitation of perfusion and detection of peri-infarct depolarisations
Laser speckle imaging of the exposed cerebral cortex allows detailed examination of the time course and topography of perfusion under …
Anthony Strong
,
Elizabeth Bezzina
,
Peter Anderson
,
Martyn Boutelle
,
Sarah Hopwood
,
Andrew Dunn
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Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex
The spatial extent of the changes in oxy-hemoglobin ($\ce{HbO}$), deoxy-hemoglobin ($\ce{HbR}$), total hemoglobin concentration …
Andrew Dunn
,
Anna Devor
,
Anders Dale
,
David Boas
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Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging
Laser speckle contrast imaging is becoming an established method for full-field imaging of cerebral blood flow dynamics in animal …
Shuai Yuan
,
Anna Devor
,
David Boas
,
Andrew Dunn
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Pronounced hypoperfusion during spreading depression in mouse cortex
We studied unique cerebral blood flow (CBF) responses to cortical spreading depression in mice using a novel two-dimensional CBF …
Cenk Ayata
,
Hwa Kyoung Shin
,
Salvatore Salomone
,
Yasemin Gürsoy-Özdemir
,
David Boas
,
Andrew Dunn
,
Michael Moskowitz
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