Particle Tracking

3D Single Particle Tracking
We built a three-dimensional single particle tracking system capable of spatial localization far beyond the diffraction limit for use in studying molecular transport dynamics.
3D Single Particle Tracking
Three-Dimensional Two-Color Dual-Particle Tracking Microscope for Monitoring DNA Conformational Changes and Nanoparticle Landings on Live Cells
Here, we present a three-dimensional two-color dual-particle tracking (3D-2C-DPT) technique that can simultaneously localize two …
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Spatial EGFR Dynamics and Metastatic Phenotypes Modulated by Upregulated EphB2 and Src Pathways in Advanced Prostate Cancer
Advanced prostate cancer is a very heterogeneous disease reflecting in diverse regulations of oncogenic signaling pathways. Aberrant …
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Assessing metastatic potential of breast cancer cells based on EGFR dynamics
Derailed transmembrane receptor trafficking could be a hallmark of tumorigenesis and increased tumor invasiveness, but receptor …
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Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1
Protein glycosylation provides proteomic diversity in regulating protein localization, stability, and activity; it remains largely …
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Segmentation of 3D trajectories acquired by TSUNAMI microscope: An application to EGFR trafficking
Whereas important discoveries made by single-particle tracking have changed our view of the plasma membrane organization and motor …
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Single-Molecule Tracking and Its Application in Biomolecular Binding Detection
In the past two decades, significant advances have been made in single-molecule detection which enables the direct observation of …
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Improving z-tracking accuracy in the two-photon single-particle tracking microscope
Here, we present a method that can improve the z-tracking accuracy of the recently invented TSUNAMI (Tracking of Single particles Using …
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Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination
Molecular trafficking within cells, tissues and engineered three-dimensional multicellular models is critical to the understanding of …
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