Phosphorescence

Oxygen Imaging
We developed imaging systems for use with oxygen-sensitive phosphorescent dyes in order to map cortical oxygen tension (pO2) and study its impact on the progression of ischemic stroke.
Oxygen Imaging
Imaging of cortical oxygen tension and blood flow following targeted photothrombotic stroke
We present a dual-modality imaging system combining laser speckle contrast imaging and oxygen-dependent quenching of phosphorescence to …
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Three-dimensional mapping of oxygen tension in cortical arterioles before and after occlusion
Occlusions in single cortical microvessels lead to a reduction in oxygen supply, but this decrement has not been able to be quantified …
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Depth dependence of vascular fluorescence imaging
In vivo surface imaging of fluorescently labeled vasculature has become a widely used tool for functional brain imaging studies. …
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Depth dependence of vascular fluorescence imaging
Improved sensitivity for two-photon frequency-domain lifetime measurement
We demonstrate a method to improve the measurement sensitivity of two-photon frequency-domain lifetime measurements in poor signal to …
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Simultaneous imaging of oxygen tension and blood flow in animals using a digital micromirror device
In this study we present a novel imaging method that combines high resolution cerebral blood flow imaging with a highly flexible map of …
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Microvascular oxygen quantification using two-photon microscopy
An instrument is demonstrated that is capable of three-dimensional (3D) vasculature imaging and $p_{O_2}$ quantification with high …
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