Spreading Depression

Imaging of cortical oxygen tension and blood flow following targeted photothrombotic stroke
We present a dual-modality imaging system combining laser speckle contrast imaging and oxygen-dependent quenching of phosphorescence to …
PDF DOI Cite LaTeX
Spreading depolarizations cycle around and enlarge focal ischaemic brain lesions
How does infarction in victims of stroke and other types of acute brain injury expand to its definitive size in subsequent days? …
PDF DOI Cite
Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia
Real-time investigation of cerebral blood flow (CBF), and oxy- and deoxyhemoglobin concentration (HbO, HbR) dynamics has been difficult …
PDF DOI Cite
Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia
Normobaric hyperoxia is under investigation as a treatment for acute ischaemic stroke. In experimental models, normobaric hyperoxia …
PDF DOI Cite
Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex
In the light of accumulating evidence for the occurrence of spontaneous cortical spreading depression and peri-infarct depolarizations …
PDF DOI Cite
Vasoconstrictive neurovascular coupling during focal ischemic depolarizations
Ischemic depolarizing events, such as repetitive spontaneous periinfarct spreading depolarizations (PIDs), expand the infarct size …
PDF DOI Cite
Evaluation of laser speckle flowmetry for imaging cortical perfusion in experimental stroke studies: quantitation of perfusion and detection of peri-infarct depolarisations
Laser speckle imaging of the exposed cerebral cortex allows detailed examination of the time course and topography of perfusion under …
PDF DOI Cite
Pronounced hypoperfusion during spreading depression in mouse cortex
We studied unique cerebral blood flow (CBF) responses to cortical spreading depression in mice using a novel two-dimensional CBF …
PDF DOI Cite
Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation
A simple instrument is demonstrated for high-resolution simultaneous imaging of total hemoglobin concentration and oxygenation and …
PDF DOI Cite
Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model
Although the trigeminal nerve innervates the meninges and participates in the genesis of migraine headaches, triggering mechanisms …
PDF DOI Cite